Prescription analysis showed that about 14,2% dispensing prescriptions contain salycilic acid mixed with cream, and 26,5% dispense prescriptions contains salicylic acid mixed with any kinds of drugs or other semi solid forms. Dispensing Salicylic acid with other semi solids were the most problems. Results of questionnaire evaluation showed that semi solid (unguentum, cream) was the major problem (69%) of pharmaceutical dispensing in the Pharmacy. The most generic name written/added was CTM (chlorpheniramin maleat). It was also found that brand names (74%) medicine were more written than generic names. The majority objective of therapy with this type of dispensing were for asthma, infection and allergy. tablet crushing was the major problems of. The result showed that the oral solid dosage forms were the majority (71%) of dispensing prescriptions written. Questionnaires and interviews to pharmacists were also conducted in order to support the prescription data. The study was conducted by sampling dispensing prescriptions from the pharmacy located in Yogyakarta. The analysis included observation problems of dosage form preparations, and examination compounds of medicines which were mentioned in dispensing prescriptions. The analysis of dispensing prescriptions available in Pharmacy in Yogyakarta was performed. Keywords : binahong leave, gelling agent, irritation test. Of the three gel preparation formulas, the score of degree of irritation was 1, 1 and 1.67, which means slight irritation (0.41-1.9). Each area observed skin reactions that occur and scored 0 to 4 depending on the severity of skin reactions produced. Observations were made after 24, 48 and 72 hours after administration of the test material. The irritant samples were smeared and then covered with sterile gauze and glued with plaster. The irritation test was performed by Draize method on three New Zealand male rabbits who had shaved the back part 24 hours prior to treatment. The aim of this research is to find out whether gel preparation of the active fraction of ethanol extract of binahong lea ve with combination of gelling agent Hydroxy Propyl Methyl Cellulose (HPMC) and carbopol can cause irritation on rabbit skin. In Material Safety Data Sheet states that Hydroxy Propyl Methyl Cellulose (HPMC) and Carbopol can cause skin irritation problems. Skin irritation test is an important part of the pharmaceutical preparation procedures. Gelling agent is the main ingredient in gel preparation. Gel is a pharmaceutical preparation with good penetration power and long contact time with skin so it can overcome the problem of acne.
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